Reactivity of Protein A and Protein G

aurion Membrane labeling with protein A 15 nm gold conjugate.
Courtesy of T.Wakefield, University of Auburn, Alabama

Species  Ig(sub)class   Protein A    Protein G

Rabbit      Ig             ++           ++

Mouse       IgG1            -            +
            IgG2a           +            +
            IgG2b           +            +
            IgG3            +           ++
            IgA             -            ?
            IgM             -            ?

Rat         IgG1            -            ?
            IgG2a           -           ++
            IgG2b           -            +
            IgG2c           +            +
            IgM             -            ?

Man         IgG1           ++           ++
            IgG2           ++           ++
            IgG3            -           ++
            IgG4           ++           ++
            IgA             -            -
            IgM             +            -
            IgD             -            -

Goat        Ig              -           ++

Sheep       Ig              -           ++

Guinea Pig  Ig             ++            +

Chicken     Ig              -            -

Pig         Ig             ++            +

Horse       Ig              -           ++

Cow         Ig              +           ++

Dog         Ig              +            +

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